For all of you who are struggling with this.... it *****! I wish Apple would have a fix or something...but it seems it is probably hardware related (endemic to the way the hardware is designed) rather than something that can be fixed by a software upgrade.
I have found a way to solve this problem...
My setup is a 2014 Mac Mini, a Vizio 55 inch 4K monitor (no tuner). I find that the only way that the monitor can wake up is when I reboot. If the computer goes to sleep...it does not wake up. I found a person's post here...with power management settings and that helped some... but that is not the nature of my "fix".
I don't want the computer to time out and sleep...or screen save...or whatever. I turned off the sleep settings on the Mac Mini.
The Solution:
I needed a way to constantly (a relative term) stimulate the display. My roommate does a lot of telework... via VPN, remote sessions, etc...and many of those systems will time out if there is no mouse movement or keyboard activity. If you get up to use the restroom, when you come back, your session is disconnected. They make something called the "Jiggler". It is a USB dongle... who's only function is to... every so often.... (10 seconds?) move the mouse by a pixel or two. This does not require you to move the mouse constantly by hand... and because it only 'jiggles' it by a pixel or two... it does not cause problems. The 'jiggling' is totally transparent.
I purchased one of these dongles...and because I have a external powered 28 port USB hub associated with my Mac Mini (Don't hate... it is truly awesome!), I had plenty of room.
My only draw back is that I have to turn the monitor off when I walk away (via the remote control) ... and don't plan on being there for a while as the way I am solving the problem obviates the whole display sleeping functionality and I don't want burn in on my awesome monitor! This is something I can do and most certainly live with. The Jiggler jiggles... and the display never sleeps and I am happy. Problem solved.
The Jiggler is the "WiebeTech Mouse Jiggler MJ-1 by CRU Inc. and (SC)Amazon.com has it for $17,99. A small price to pay
So, in a nutshell... things are good... and I am enjoying my 55" LED 4K monitor!
Good luck ;-)