mouse pointer jumping around since 10.10.3

There are several possible causes for this issue. Please take each of the following steps that you haven't already tried until it's resolved. Some may not apply in your case.

1. Follow the instructions in this support article, and also this one, if applicable. A damaged or defective AC adapter could be the cause, even if it's the right kind.

2. Press down all four corners of the trackpad at once and release. If there's any effect, it's likely to be temporary, and in that case the unit must be serviced or replaced.

3. Open the Bluetooth pane in System Preferences and delete all pointing devices other than the trackpad, if applicable. Disconnect any USB pointing devices. By a "pointing device," I mean a peripheral that moves the cursor, such as a trackpad, mouse, trackball, or graphics tablet. A plain keyboard is not a pointing device.

4. If your model has an infrared receiver for use with an Apple Remote, disable it.

5. Start up in safe mode and test, preferably without launching any third-party applications. If you don't have the problem in safe mode, but it comes back when you restart as usual, stop here and post your results. Do the same if you can't start in safe mode. If there was no difference in safe mode, go on to the next step.

6. Reset the System Management Controller.

7. If you're using a Bluetooth trackpad or mouse, investigate potential sources of interference, including USB 3 devices.

8. A swollen battery in a portable computer can impinge on the trackpad from below and cause erratic behavior. If you have trouble clicking the trackpad, this is likely the reason. The battery must be replaced without delay.

9. A defective peripheral device or a damaged cable can cause the built-in trackpad of a MacBook to behave erratically. If you're using any wired peripherals, disconnect them one at a time and test.

10. There's also a report of erratic cursor movements caused by an external display that was connected but not turned on.

11. If none of the above applies, or if you have another reason to think that your computer is being remotely controlled, remove it from the network by turning off Wi-Fi (or your Wi-Fi access point), disconnecting from a Bluetooth network link, and unplugging the Ethernet cable or USB modem, whichever is applicable. If the cursor movements stop at once, you should suspect an intrusion.

12. Make a "Genius" appointment at an Apple Store to have the machine and/or external trackpad tested.

Are you still having this problem? Disable HandOff on your iDevices and iMac. All should be well. It's a known bug apparently.

See THIS THREAD ...

J.

Just fyi, I experienced this issue as well. My resolution was related to:

10. There's also a report of erratic cursor movements caused by an external display that was connected but not turned on.

I noticed my external display wouldn't come on. After reseting it the cursor jump seems to have vanished.