Safari not responding

Hi there, I get the wheel of death every time I try and load my safari. Safari wont load and I cant even get into the Safri menu "safari not responding" either is my email. Any ideas how I can remove cookies without going through Safari? Also I keep getting pop up windows asking me for my keychain password, but the apps that are asking for my keychain I do not recognise so I don't want to put in my password. pressing cancel does not get rid of these pop ups.