There are various web pages that show the manual method to remove this garbage. How recent they are will determine how well they work. But for your basic question, you need to remove the startup item in your user account. Open the System Preferences and click on Users & Groups, then your account name in the left column. Click on Login Items at the right. Highlight any reference to Advanced Mac Cleaner or Mac Defender. Click the - button to remove it.
This only stops the automatic launch at startup or restart. Follow the directions at the bottom of this site to remove items related to Advanced Mac Cleaner. Note that the first step is the kill the process already running in RAM by using the Activity Monitor. Do that before removing the Login Items entry.
If you do any other searching around, be aware of sites like this one. They list the first method as downloading MacKeeper to remove Advanced Mac Cleaner. MacKeeper itself is as much of a scam as AMC. That's like using a sledgehammer to fix your watch. They do at least add some useful manual information by adding file locations to look for. At the same time, they very idiotically suggest removing the entire Applications folder! Now, they may have used Paint 2 as an example of removing a suspicious app within the Applications folder, but that's not how they wrote the wording above the image. It simply says, >>Applications >> Move to Trash. I could see a lot of inexperienced users putting the entire Applications folder in the trash following the instructions verbatim.
Advanced Mac Cleaner has a removal tool for download on their own site, but I wouldn't trust that to do what it says for a moment.
Notice that between the two sites, the files they list to find and manually remove are different. That's part of why these types of apps are so difficult to remove. The makers of this crap keep changing the names of the files, the number of them they install, and where on the drive they're installed to. So even these together may not get everything. To summarize:
1) Make a full backup before proceeding with manual instructions. Accidentally removing the wrong thing (like the entire Library folder either at the root of the drive, or the same named folder in your user account) will require reinstalling the backup.
2) Open Activity Monitor in the /Applications/Utilities/ folder. Sort by name and look for Advanced Mac Cleaner or Mac Defender in the list. Highlight it (or both, one at a time) and click the X button to kill the process.
3) Remove the similarly named entry from your Login Items.
4) Locate and remove any of these files you find. The tilde ~ means they're in your user account, not the main Library folder.
/Library/Application Support/Advanced Mac Cleaner/
~/Library/Internet Plug-Ins/Advanced Mac Cleaner NPAPIPlugin.plugin
/Library/PrivilegedHelperTools/Jack
/Library/InputManagers/CTLoader/
/System/Library/Frameworks/Advanced Mac Cleaner.framework
~/Library Folder – Advanced Mac Cleaner; hlpramc
~/Library/Logs – Advanced Mac Cleaner.log; helperamc.log
~/Library/Application Support – Advanced Mac Cleaner; amc
~/Library/Caches – com.pcv.hlpramc; com.PCvark.Advanced-Mac-Cleaner
~/Library/Saved Application State – com.PCvark.Advanced-Mac-Cleaner.savedState
~/Library/Preferences – com.pcv.hlpramc.plist; com.PCvark.Advanced-Mac-Cleaner.plist
~/Library/LaunchAgents – com.pcv.hlpramc.plist; com.PCvark.Advanced-Mac-Cleaner.plist
