USB Headphone on iPhone 5s

maybe, most likely not

usb headset are not headsets as such really they are external soundcards that mean they are not feed an analogue audio stream like a 3.5mm minijack headset would, they get universal serial bus commands and digital data streams to interp those one needs to install a device driver on the computer something which one can't do on an ios device

if you want headsets you can be sure works with ios devices use 1 headsets with a 3.5mm minijack connector or 2 bluetooth stereo headsets which support the a2dp bluetooth profile