This helped me. I had to do it more than once though. I don't use Mail so had no problems with that. I have 16GB RAM and nothing in CPU or Memory on Activity Monitor was showing as hogging. Every time I tried to open a Finder window I'd have the beach ball.
I completed this step and in addition:
1) System Preferences-> Users and Groups->Login Items
-Remove any unnecessary items
-In particular, removed Adobe Resource Synchronizer app was starting up at login every time and has been associated with slow loading times
-checked Library->LaunchAgents for any reference to these apps
2) Checked Activity Monitor for any rogue processes particularly Mac_Swapper Demon
-used to use a dongle but no longer do so forced quit Mac_Swapper Demon and ensured this was deleted
3) Quit Word and other Office programs which were horrifically laggy.
4) System Preferences->Spotlight
-unchecked everything apart from Applications
-unchecked Allow Spotlight suggestions
5) System Preferences-> Dock
-Minimise windows using SCALE EFFECT
6) System Preferences->Accessibility->Display
-Reduce transparency
7) Uninstalled and deleted old Blackberry Desktop Managers, Perian, other third party apps that I no longer use
8) Shut down once again, completed the Cmd+Ctrl+Shift step AGAIN...
9) Opened Spotlight and searched for KeyChain Access and I saw a blue bar with 'Indexing' appear... waited until this disappeared before touching the MacBook. Completed Keychain First Aid on Keychain Access and all seems to be working now...
Couldn't tell you which of these was the helper but try them all!