Zinio Delivery Manager UNKNOWN (missing value)
Do you know what this is? When I Google it, I am not finding nice things being said.
I am seeing some references to it being a cleaning app on the Mac. Long time forum contributors have found that Mac cleaning apps cause more trouble than they are worth. Along with any anti-virus apps, and memory cleaner apps. We find user systems run better without any of these 3rd party apps.
If you do know what is it, and if it is performing a service you value, then OK. Otherwise, I suggest you consider removing it.
<http://www.securitystronghold.com/gates/zinio-delivery-manager.html>
Time Machine information requires OS X 10.8 "Moutain Lion" or later
This is most likely just EtreCheck saying it does not know how to get Time Machine detailed information on a version of OS X before Mountain Lion. I do not think EtreCheck is saying anything bad about your Time Machine backup setup. I'm assuming you have backups happening, if not via Time Machine, then via some other backup utility/service.
I am not seeing anything else of interest on your system.
You might try booting into Safe mode as an experiment
<http://support.apple.com/kb/ht1564>
Safe mode will not load 3rd party additions and see if there is a significant difference. You do not want to run full time in Safe mode, but it is a good experiment to see if 3rd party stuff is causing issues.
You might try the Terminal -> sar -g ... experiment above, letting it run to see if you are experiencing any paging/swapping issues. I suspect not, as you have 8GB of RAM and unless you are doing large format photo editing or video editing, you are most likely not going to over stress your RAM.
Granted, you system was up less than an hour when you ran EtreCheck. The EtreCheck output might have more information if it was run at the time you are seeing your system performance issues.
By the way, you can just copy and paste the EtreCheck output directly into a reply. You do not need to print to PDF, and post on Dropbox. But if you like that better it is OK too.
Finally, if you do decide you are going to replace the disk yet again (and I do not see any reason it is the disk), then consider an SSD. It will put "Spring" in your Mac mini's step đ But seriously, do not spend money on something that you may not need.