File Vault full disk encryption won't have any effect on your cloud services. When you login the disk is decrypted this means any cloud services can access the same data as you - in it's decrypted form. The documents uploaded will not be encrypted (unless the service does it's own encryption too).
See the providers for more detail. iCloud has this info…
iCloud security and privacy overview - Apple Support
You can encrypt files before you upload them to any cloud services - but that is separate to File Vault.
File Vault has a few potential disadvantages…
If the disk fails recovering data is harder because the data is encrypted - Make good backups & test them!
The computer is decrypting data 'on the fly' that means it is doing more work than a system without encryption. The performance difference is probably not noticeable with newer Macs unless you start using benchmark tools.
Forgetting/ losing the password & recovery key will render the data inaccessible!
The advantage is obvious, your files are not accessible to anyone unless they have the password (or they access the device when you have logged in). Normally the files on a Mac can be read if someone has the know how to access the disk, that info is available all over the internet 🙂
e.g. OS X Mountain Lion: Transfer files between two computers using target disk mode
It really depends if you need to protect your data 'at rest' (when the device is powered off). File Vault will not protect you from any malware or other bad software etc. This is because the OS is effectively the same when in use - once the data is decrypted it is accessible, which is why File Vault likes you to lock the screen with a screen saver password.
See the File Vault info if you haven't already done so…
Use FileVault to encrypt the startup disk on your Mac - Apple Support