A user at my office recently upgraded a mac to SierraOS. As part of my recurring maintenance, I tested a recovery of the backup jobs from our Synology Time Capsule. I was a little rusty, so my process might have been incorrect, but when I tried to restore from the Time Capsule on a test machine, it failed. I had to gain access to the production mac (the one that was upgraded) and although the Synology was still attached and readable from the machine, the backups were failing. When I removed and re-added the Synology as the backup device, Time Machine was able to recognize the Time Capsule and the image that was currently on it, but gave a popup error that essentially said the backup image was corrupt and had to be recreated. After allowing it to recreate, it has run incremental backups without any issues ever since. We use Vipre AV at the moment, so I didn't need to deactivate AV (I know it's not the best for Macs, but we're a mostly Windows environment).
Summary of events (because my paragraphs have a tendency to blur):
1. (Pre-OS upgrade) Verify TM backups are functional.
2. Upgrade Mac to SierraOS.
3. Cannot recover the TM instances.
4. Remove and re-add Time Capsule from TM.
5. Force TM backup job and allow it to recreate the backup image.
6. After first backup job, verify new backup images are recoverable.
7. Followed up after a week and verified they were still working.
Everything in this post happened within the past month.