Hi,
I've the same problem here, like Pawel with an external DELL UP2414Q connected via DisplayPort 1.2 to a MacBook Pro (Retina, 15-inch, mid 2014) running macOS Sierra 10.12.
I used it all the time with OS X Yosemite and El Capitan with DP 1.2 60Hz. After I'd upgraded to macOS Sierra last week, I faced problems with the mouse. The cursor shape often was not fitting to it's position, for example meaning it was the "normal" arrow shape although it was above the right border of Mail's window, where it has to be the double left-right arrow indicating that the window can be resized. Moving the mouse out of Mail's window (more to the right) ended up with the resize shape some pixels right of the window, where click and hold enabled me to resize the window.
I had these problems with other macOS applications and with Windows 10 running on Parallels. They occured from time to time and they disappeared without changing anything. But for me as a developer the system was useless, because I was no longer able to design GUI elements or simple work with drag and drop.
After I read Pawel's initial message here I switched the DELL display to DP 1.1 two days ago and since then the problem has gone. So there seems to be an issue with Sierra and at least these DELL displays.
Anyone with an idea? Would be great to work with 60 Hz again, because animations are awful in 30 Hz.
Regards, Lars