I have had the same problem when running Safari, MS Word for Mac, Adobe Reader, Firefox. Tried the EtreCheck program, here are the results.
EtreCheck version: 3.0.6 (315)
Report generated 2016-10-10 17:06:53
Download EtreCheck from https://etrecheck.com
Runtime 2:49
Performance: Excellent
Click the [Support] links for help with non-Apple products.
Click the [Details] links for more information about that line.
Click the [Remove] links to remove adware.
Problem: Other problem
Description:
Black or white rectangles obscure the desktop or other windows open on the desktop. These cannot be removed without restarting. Very annoying.
Hardware Information: ⓘ
iMac (27-inch, Mid 2010)
[Technical Specifications] - [User Guide] - [Warranty & Service]
iMac - model: iMac11,3
1 3.2 GHz Intel Core i3 CPU: 2-core
12 GB RAM Upgradeable - [Instructions]
BANK 0/DIMM0
2 GB DDR3 1333 MHz ok
BANK 1/DIMM0
2 GB DDR3 1333 MHz ok
BANK 0/DIMM1
4 GB DDR3 1333 MHz ok
BANK 1/DIMM1
4 GB DDR3 1333 MHz ok
Bluetooth: Old - Handoff/Airdrop2 not supported
Wireless: en1: 802.11 a/b/g/n
Video Information: ⓘ
ATI Radeon HD 5670 - VRAM: 512 MB
iMac 2560 x 1440
System Software: ⓘ
macOS Sierra 10.12 (16A323) - Time since boot: about 5 hours
Disk Information: ⓘ
WDC WD1001FALS-40Y6A0 disk0 : (1 TB) (Rotational)
EFI (disk0s1) <not mounted> : 210 MB
Byron's iMac (disk0s2) / [Startup]: 999.35 GB (86.29 GB free)
Recovery HD (disk0s3) <not mounted> [Recovery]: 650 MB
HL-DT-STDVDRW GA32N ()
USB Information: ⓘ
Apple, Inc. Keyboard Hub
Apple, Inc Apple Keyboard
Apple Card Reader
Apple Inc. BRCM2046 Hub
Apple Inc. Bluetooth USB Host Controller
CP1000PFCLCD CRDA103.981
Apple Computer, Inc. IR Receiver
Apple Inc. Built-in iSight
Gatekeeper: ⓘ
Mac App Store and identified developers
Adware: ⓘ
~/Library/LaunchAgents/com.unionsoftwareonline.AppMonitor.plist
One adware file found. [Remove]
System Launch Agents: ⓘ
[not loaded] 7 Apple tasks
[loaded] 168 Apple tasks
[running] 96 Apple tasks
System Launch Daemons: ⓘ
[not loaded] 42 Apple tasks
[loaded] 161 Apple tasks
[running] 100 Apple tasks
Launch Agents: ⓘ
[loaded] com.oracle.java.Java-Updater.plist (2015-12-11) [Support]
Launch Daemons: ⓘ
[loaded] com.adobe.fpsaud.plist (2016-08-29) [Support]
[loaded] com.malwarebytes.HelperTool.plist (2016-06-28) [Support]
[loaded] com.oracle.java.Helper-Tool.plist (2015-12-11) [Support]
User Launch Agents: ⓘ
[running] com.amazon.music.plist (2016-02-12) [Support]
[loaded] com.citrixonline.GoToMeeting.G2MUpdate.plist (2016-10-07) [Support]
[running] com.spotify.webhelper.plist (2016-04-05) [Support]
[failed] com.unionsoftwareonline.AppMonitor.plist (2016-08-17) Adware! [Remove]
User Login Items: ⓘ
System Events Application (/System/Library/CoreServices/System Events.app)
AirPort Base Station Agent Application (/System/Library/CoreServices/AirPort Base Station Agent.app)
Microsoft Database Daemon Application (/Applications/Microsoft Office 2008/Office/Microsoft Database Daemon.app)
Dropbox Application (/Applications/Dropbox.app)
Internet Plug-ins: ⓘ
MeetingJoinPlugin: Unknown - SDK 10.2 (2016-04-30) [Support]
OfficeLiveBrowserPlugin: 12.3.6 (2013-03-25) [Support]
Flip4Mac WMV Plugin: 3.2.0.16 - SDK 10.8 (2013-12-03) [Support]
AdobePDFViewerNPAPI: 10.1.16 (2015-10-30) [Support]
FlashPlayer-10.6: 23.0.0.162 - SDK 10.9 (2016-10-07) [Support]
Silverlight: 5.1.50709.0 - SDK 10.6 (2016-10-04) [Support]
QuickTime Plugin: 7.7.3 (2016-09-13)
Flash Player: 23.0.0.162 - SDK 10.9 (2016-10-07) [Support]
iPhotoPhotocast: 7.0 (2010-05-06)
AdobePDFViewer: 10.1.16 (2015-10-30) [Support]
CouponPrinter-FireFox_v2: Version 1.1.6 (2011-07-27)
GarminGpsControl: 4.0.3.0 Release - SDK 10.6 (2013-10-21) [Support]
JavaAppletPlugin: Java 8 Update 101 build 13 (2016-07-25) Check version
User internet Plug-ins: ⓘ
CitrixOnlineWebDeploymentPlugin: 1.0.105 (2013-04-25) [Support]
WebEx64: 1.0 - SDK 10.10 (2015-09-30) [Support]
Safari Extensions: ⓘ
QuickBrowse - Catalin Andrei Vasiliu - http://www.unionsoftwareonline.com (2016-04-06)
3rd Party Preference Panes: ⓘ
Flash Player (2016-08-29) [Support]
Flip4Mac WMV (2013-03-29) [Support]
Java (2016-07-25) [Support]
Perian (2011-07-23) [Support]
Time Machine: ⓘ
Time Machine not configured!
Top Processes by CPU: ⓘ
13% WindowServer
5% Safari
5% AdobeReader
4% kernel_task
2% com.apple.WebKit.WebContent(12)
Top Processes by Memory: ⓘ
4.03 GB com.apple.WebKit.WebContent(12)
897 MB kernel_task
418 MB iTunes
344 MB mdworker(11)
319 MB Safari
Virtual Memory Information: ⓘ
1.90 GB Free RAM
10.00 GB Used RAM (3.23 GB Cached)
0 B Swap Used
Diagnostics Information: ⓘ
Oct 10, 2016, 03:24:23 PM ~/Library/Logs/DiagnosticReports/Mail_2016-10-10-152423_[redacted].crash
com.apple.mail - /Applications/Mail.app/Contents/MacOS/Mail
Oct 10, 2016, 01:01:51 PM ~/Library/Logs/DiagnosticReports/SystemUIServer_2016-10-10-130151_[redacted].cr ash
com.apple.systemuiserver - /System/Library/CoreServices/SystemUIServer.app/Contents/MacOS/SystemUIServer
Oct 10, 2016, 01:01:51 PM ~/Library/Logs/DiagnosticReports/UserEventAgent_2016-10-10-130151_[redacted].cr ash
/usr/libexec/UserEventAgent
Oct 10, 2016, 01:01:50 PM ~/Library/Logs/DiagnosticReports/sharingd_2016-10-10-130150_[redacted].crash
/usr/libexec/sharingd
Oct 10, 2016, 01:01:42 PM /Library/Logs/DiagnosticReports/mediaremoted_2016-10-10-130142_[redacted].crash
/System/Library/PrivateFrameworks/MediaRemote.framework/Support/mediaremoted
Oct 10, 2016, 01:01:40 PM /Library/Logs/DiagnosticReports/wifivelocityd_2016-10-10-130140_[redacted].cras h
/usr/libexec/wifivelocityd
Oct 10, 2016, 11:15:40 AM Self test - passed
Oct 8, 2016, 11:21:49 AM ~/Library/Logs/DiagnosticReports/QuickLookSatellite_2016-10-08-112149_[redacted ].crash
/System/Library/Frameworks/QuickLook.framework/Versions/A/Resources/quicklookd. app/Contents/XPCServices/QuickLookSatellite.xpc/Contents/MacOS/QuickLookSatellit e