I am not for one moment suggesting my case is the norm but after years of bitter experience I have always tried to avoid updating mac os because of previous (expensive) issues with adobe!
However, as iTunes have now upgraded their security which involved validation codes I was forced to do that very thing yesterday. I plumbed the internet and was left feeling very insecure but went for it so upgraded from Yosemite to Sierra.
I have adobe CS5.5 and I tried to open the programs and nothing seemed to happen for a long time. To be fair I think my old Mid 2011 iMac was still coming to terms with the trauma of the update.
Eventually, photoshop opened followed by illustrator and then indesign. It took a long time but after that initial wait they seem to open normally. I made a couple of very slight changes in each program to projects I have and they seemed fine but I have not carried out any in depth research. I am happy that so far so good and no crashes....
I have indesign 7.0