I have a lab with a number of Mac Pro 5,1 from 2010 and 2012, all upgraded -- 2x3.33 or 3.46 Ghz CPUs, max RAM in some cases, internal and external SSD and rotating drives of various types and capacities (2-8TB), upgraded GPUs, USB 3, etc. In the most-used Mac Pro, I can confirm that since upgrading to High Sierra, I have had round-robin drive failures -- it seems that something, and I have not yet been able to identify any specific cause, is causing internal and external rotating drives to experience corruption. One or more drives fail, cannot be repaired, but can still be mounted and accessed read-only, so data can be copied to another drive, the failed drive reformatted, and the data copied back. Then within a few days, the process repeats. This has cost many hours of work, but thanks to good backup routines, nothing so far has been lost. The real pain (and stress) is when the external drives holding Time Machine backups fail, and that has happened several times now.
Interestingly, the boot drive on the most-used machine is an SSD that was auto-converted to APFS when HS was installed -- that drive appears to be working fine, but Disk Utility will not repair it. Other internal SSDs (not using APFS) located on a PCI card seem to be more stable, though one Bootcamp partition on an internal SSD did get corrupted and had to be reformatted.
It is beyond statistically improbable that all of these drives are suddenly failing at the same time. There are numerous possibilities, but I have eliminated a number of them so far, and the most likely culprit remaining is High Sierra. Interestingly, rotating drives reformatted as APFS instead of HFS+ seem so far to be more stable. I am seriously considering reverting to Sierra for my Mac Pros. I'll post again if I have more data to add.