Hi Kai199! I´ll answer this with a conditional "yes", because I don't know how you use CS6: my CS6 (DVD version) works fine for my needs on my iMac running High Sierra 10.13.1, but you might want to read this thread first, which discusses one problem (bug?)...
Re: CS6 not working on Sierra - please help!
If you have your files displayed as "free-floating" and not as tabs then closing a file will cause CS6 to crash. The post shows you how to set CS6 preferences to avoid this. I've not encountered any other problems with CS6 and High Sierra, but then I'm not really a "power user. In some article I read removing all 11 CS6 pre-installed plug-ins was suggested. These plug-ins are found here: /Applications/Adobe Photoshop CS6/Plug-ins. It would also be a good idea to do a clean install of CS6 if you do upgrade to High Sierra. Hope this helps you! Cheers, Ian.