Thanks very much. Here's the EtreCheck report.
Note that the behaviour is not currently occurring. I set the default to Acrobat earlier today and so far it has stuck. But I have done this several times recently and the issue reoccurs frequently.
***
EtreCheck version: 3.4.7 (461)
Report generated 2018-02-14 21:20:15
Download EtreCheck from https://etrecheck.com
Runtime: 11:22
Performance: Poor
Click the [Lookup] links for more information from Apple Support Communities.
Click the [Details] links for more information about that line.
Click the [Clean up] link to delete unused files.
Problem: Other problem
Description:
Default app for PDF keeps changing
Hardware Information: ⓘ
iMac (Retina 5K, 27-inch, Late 2015)
[Technical Specifications] - [User Guide] - [Warranty & Service]
iMac - model: iMac17,1
1 3.3 GHz Intel Core i5 (i5-6600) CPU: 4-core
24 GB RAM Upgradeable - [Instructions]
BANK 0/DIMM0
4 GB DDR3 1867 MHz ok
BANK 0/DIMM1
8 GB DDR3 1867 MHz ok
BANK 1/DIMM0
4 GB DDR3 1867 MHz ok
BANK 1/DIMM1
8 GB DDR3 1867 MHz ok
Handoff/Airdrop2: supported
Wireless: en1: 802.11 a/b/g/n/ac
iCloud Quota: 31.03 GB available
Video Information: ⓘ
AMD Radeon R9 M395 - VRAM: 2 GB
iMac 5120 x 2880
S2410W 1920 x 1200
Disk Information: ⓘ
APPLE HDD ST2000DM001 disk0: (2 TB) (Rotational)
[Show SMART report]
EFI (disk0s1 - MS-DOS FAT32) <not mounted> [EFI]: 210 MB
(disk0s2) <not mounted> [CoreStorage Container]: 2.00 TB
Recovery HD (disk0s3 - Journaled HFS+) <not mounted> [Recovery]: 650 MB
APPLE SSD SM0128G disk1: (121.33 GB) (Solid State - TRIM: Yes)
[Show SMART report]
EFI (disk1s1 - MS-DOS FAT32) <not mounted> [EFI]: 210 MB
(disk1s2) <not mounted> [CoreStorage Container]: 120.99 GB
(disk1s3) <not mounted> [Boot]: 134 MB
USB Information: ⓘ
USB30Bus
Samsung M3 Portable Samsung M3 Portable
M3 Portable disk4: (2 TB)
EFI (disk4s1 - MS-DOS FAT32) <not mounted> [EFI]: 210 MB
iMac clone (disk4s2 - Journaled HFS+) /Volumes/iMac clone : 2.00 TB (83.77 GB free)
Recovery HD (disk4s3 - Journaled HFS+) <not mounted> [Recovery]: 650 MB
VIA Labs, Inc. USB3.0 Hub
HGST G-Drive Mobile
541010A9E680 disk3: (1 TB)
EFI (disk3s1 - MS-DOS FAT32) <not mounted> [EFI]: 210 MB
Photo & Movie Archive (disk3s2 - Journaled HFS+) /Volumes/Photo & Movie Archive : 999.86 GB (175.98 GB free)
Broadcom Corp. Bluetooth USB Host Controller
Apple Inc. FaceTime HD Camera (Built-in)
VIA Labs, Inc. USB2.0 Hub
Seagate GoFlex Pro Mac
GoFlex Pro Mac disk5: (1 TB)
EFI (disk5s1 - MS-DOS FAT32) <not mounted> [EFI]: 210 MB
Job Archive (disk5s2 - Journaled HFS+) /Volumes/Job Archive : 999.86 GB (754.50 GB free)
Apple, Inc. Keyboard Hub
Apple Inc. Apple Keyboard
Thunderbolt Information: ⓘ
Apple Inc. thunderbolt_bus
Virtual disks: ⓘ
Macintosh HD (disk2 - Journaled HFS+) / [Startup]: 2.11 TB (924.04 GB free)
Physical disk: disk1s2 120.99 GB Online
Physical disk: disk0s2 2.00 TB Online
System Software: ⓘ
macOS High Sierra 10.13.3 (17D47) - Time since boot: about 14 hours
Gatekeeper: ⓘ
Mac App Store and identified developers
Clean up: ⓘ
/Library/LaunchAgents/com.epson.esua.launcher.plist
/Applications/Epson Software/EPSON Software Updater.app/Contents/EPSON Software Updater Agent.app/Contents/MacOS/EPSON Software Updater Agent
Executable not found!
One orphan file found. [Clean up]
Kernel Extensions: ⓘ
/Library/Extensions
[loaded] com.Cycling74.driver.Soundflower (2.0b2 - SDK 10.10) [Lookup]
[loaded] com.sophos.kext.oas (9.7.0 - SDK 10.12) [Lookup]
[loaded] com.sophos.nke.swi (9.7.0 - SDK 10.12) [Lookup]
System Launch Agents: ⓘ
[not loaded] 9 Apple tasks
[loaded] 169 Apple tasks
[running] 112 Apple tasks
System Launch Daemons: ⓘ
[not loaded] 35 Apple tasks
[loaded] 181 Apple tasks
[running] 115 Apple tasks
Launch Agents: ⓘ
[failed] com.adobe.ARMDCHelper.cc24aef4a1b90ed56a725c38014c95072f92651fb65e1bf9c8e43c37a 23d420d.plist (Adobe Systems, Inc. - installed 2018-02-13) [Lookup]
[running] com.adobe.AdobeCreativeCloud.plist (Adobe Systems, Inc. - installed 2018-02-06) [Lookup]
[loaded] com.adobe.GC.Invoker-1.0.plist (Adobe Systems, Inc. - installed 2018-01-31) [Lookup]
[running] com.epson.epw.agent.plist (? 7c4cf380 5b21e787 - installed 2017-01-30) [Lookup]
[failed] com.epson.esua.launcher.plist (? 70512568 0 - installed 2017-11-07) [Lookup] - /Applications/Epson Software/EPSON Software Updater.app/Contents/EPSON Software Updater Agent.app/Contents/MacOS/EPSON Software Updater Agent: Executable not found!
[loaded] com.google.keystone.agent.plist (Google, Inc. - installed 2017-09-28) [Lookup]
[loaded] com.microsoft.update.agent.plist (Microsoft Corporation - installed 2018-01-24) [Lookup]
[running] com.sophos.agent.plist (Sophos - installed 2018-01-25) [Lookup]
[running] com.sophos.home.ui.plist (Sophos - installed 2018-01-25) [Lookup]
Launch Daemons: ⓘ
[running] com.adobe.ARMDC.Communicator.plist (Adobe Systems, Inc. - installed 2018-02-13) [Lookup]
[running] com.adobe.ARMDC.SMJobBlessHelper.plist (Adobe Systems, Inc. - installed 2018-02-13) [Lookup]
[loaded] com.adobe.acc.installer.plist (Adobe Systems, Inc. - installed 2018-02-06) [Lookup]
[running] com.adobe.agsservice.plist (Adobe Systems, Inc. - installed 2018-01-31) [Lookup]
[loaded] com.adobe.fpsaud.plist (Adobe Systems, Inc. - installed 2018-02-01) [Lookup]
[running] com.backblaze.bzserv.plist (Backblaze - installed 2018-02-02) [Lookup]
[running] com.bombich.ccchelper.plist (Bombich Software, Inc. - installed 2018-01-08) [Lookup]
[running] com.crashplan.proserver.plist (? 7d305767 8ab793d2 - installed 2016-05-16) [Lookup]
[loaded] com.google.keystone.daemon.plist (Google, Inc. - installed 2017-10-13) [Lookup]
[loaded] com.linotype.FontExplorerX.securityhelper.plist (Linotype GmbH - installed 2016-02-22) [Lookup]
[loaded] com.macpaw.CleanMyMac3.Agent.plist (MacPaw Inc. - installed 2017-12-04) [Lookup]
[loaded] com.microsoft.autoupdate.helper.plist (Microsoft Corporation - installed 2018-01-24) [Lookup]
[loaded] com.microsoft.office.licensingV2.helper.plist (Microsoft Corporation - installed 2016-02-12) [Lookup]
[loaded] com.sharpcast.xfsmond.plist (? 685406c7 0 - installed 2018-01-30) [Lookup]
[running] com.sophos.common.servicemanager.plist (Sophos - installed 2018-01-25) [Lookup]
User Launch Agents: ⓘ
[loaded] com.adobe.AAM.Updater-1.0.plist (Adobe Systems, Inc. - installed 2017-10-20) [Lookup]
[loaded] com.adobe.GC.Invoker-1.0.plist (Adobe Systems, Inc. - installed 2018-01-31) [Lookup]
[running] com.backblaze.bzbmenu.plist (Backblaze - installed 2018-02-14) [Lookup]
[loaded] com.dropbox.DropboxMacUpdate.agent.plist (Dropbox, Inc. - installed 2017-08-26) [Lookup]
[not loaded] com.linotype.FontFolderProtector.plist (Linotype GmbH - installed 2018-01-03) [Lookup]
[running] com.spotify.webhelper.plist (Spotify - installed 2018-02-09) [Lookup]
User Login Items: ⓘ
CCC User Agent Application (Bombich Software, Inc. - installed 2018-01-08)
(/Applications/Carbon Copy Cloner.app/Contents/Library/LoginItems/CCC User Agent.app)
Billings Pro Sync Helper SMLoginItem - Hidden (Marketcircle Inc - installed 2017-12-04)
(/Applications/Billings Pro.app/Contents/Library/LoginItems/Billings Pro Sync Helper.app)
Internet Plug-ins: ⓘ
AdobeAAMDetect: 3.0.0.0 (installed 2018-02-06) [Lookup]
FlashPlayer-10.6: 28.0.0.161 (installed 2018-02-06) [Lookup]
QuickTime Plugin: 7.7.3 (installed 2018-01-25)
AdobePDFViewerNPAPI: 17.012.20098 (installed 2018-02-14) [Lookup]
AdobePDFViewer: 18.011.20035 (installed 2018-02-14) [Lookup]
Flash Player: 28.0.0.161 (installed 2018-02-06) [Lookup]
o1dbrowserplugin: 5.41.3.0 (installed 2015-12-11) [Lookup]
PepperFlashPlayer: 28.0.0.161 (installed 2018-02-07) [Lookup]
googletalkbrowserplugin: 5.41.3.0 (installed 2015-12-11) [Lookup]
Safari Extensions: ⓘ
[enabled] Adblock Plus - Eyeo GmbH - https://adblockplus.org/ (installed 2017-09-20)
[enabled] LastPass - LastPass - https://lastpass.com/ (installed 2017-11-16)
3rd Party Preference Panes: ⓘ
Backblaze Backup (installed 2018-02-02) [Lookup]
Flash Player (installed 2018-02-01) [Lookup]
FUSE for macOS (installed 2016-09-26) [Lookup]
Paragon NTFS for Mac ® OS X (installed 2017-12-04) [Lookup]
Xmarks for Safari (installed 2015-03-04) [Lookup]
Time Machine: ⓘ
Skip System Files: NO
Mobile backups: OFF
Auto backup: NO - Auto backup turned off
Volumes being backed up:
Macintosh HD: Disk size: 2.11 TB Disk used: 1.19 TB
Job Archive: Disk size: 999.86 GB Disk used: 245.36 GB
Destinations:
TimeMachine [Local]
Total size: 2.00 TB
Total number of backups: 57
Oldest backup: 27/04/2016, 19:05
Last backup: 05/10/2016, 21:08
Size of backup disk: Too small
Backup size 2.00 TB < (Disk used 1.44 TB X 3)
Top Processes by CPU: ⓘ
24% SophosAutoUpdate
12% kernel_task
8% WindowServer
5% plugin-container
5% plugin-container
Top Processes by Memory: ⓘ
5.81 GB kernel_task
3.90 GB Adobe Lightroom Classic
1.40 GB firefox
1024 MB plugin-container
882 MB bztransmit
Top Processes by Network Use: ⓘ
Input Output Process name
7 MB 74 KB SophosWebIntelligence
1 MB 2 MB SophosMcsAgentD
1 MB 179 KB mDNSResponder
493 KB 214 KB Mail
223 KB 162 KB SugarSync
Top Processes by Energy Use: ⓘ
18.04 bztransmit
8.46 WindowServer
8.40 coreaudiod
7.42 plugin-container
Virtual Memory Information: ⓘ
4.10 GB Available RAM
49 MB Free RAM
19.90 GB Used RAM
4.06 GB Cached files
997 MB Swap Used
Software installs (last 30 days): ⓘ
Slack: 3.0.5 (installed 2018-01-18)
Microsoft Excel for Mac: (installed 2018-01-22)
Microsoft Word for Mac: (installed 2018-01-22)
Microsoft OneNote for Mac: (installed 2018-01-22)
Microsoft PowerPoint for Mac: (installed 2018-01-22)
Microsoft Outlook for Mac: (installed 2018-01-22)
Microsoft AutoUpdate: (installed 2018-01-24)
Microsoft Word for Mac: (installed 2018-01-27)
Microsoft PowerPoint for Mac: (installed 2018-01-27)
Moon Invoice Pro: 1.6.8 (installed 2018-01-29)
Adobe Flash Player: (installed 2018-02-06)
Adobe Pepper Flash Player: (installed 2018-02-07)
ARMDC Agent Installer: (installed 2018-02-13)
Adobe Acrobat DC (18.011.20035): (installed 2018-02-14)
Microsoft Word for Mac: (installed 2018-02-14)
Microsoft Excel for Mac: (installed 2018-02-14)
Microsoft PowerPoint for Mac: (installed 2018-02-14)
Install information may not be complete.
Diagnostics Events (last 3 days for minor events): ⓘ
2018-02-14 06:55:00 Last shutdown cause: 0 - Power loss
2018-02-13 21:07:09 Adobe Illustrator.app Crash [Open]
2018-02-12 07:42:02 Adobe InDesign CC 2018.app High CPU use [Open] [Details]