Is there any way to use a Dymo 4xl printer with an iPad Pro?

For an iPad to directly use a printer, it needs to be AirPrint compatible and be connected to the same Wifi network as the iPad.

About AirPrint - Apple Support

The Dymo does not appear to be AirPrint compatible, nor even wireless.

If it can be connected to a computer, there is software out there that as mentioned that can share the printer out to iOS devices.

There also appears to be a Dymo App, though I'm not entirely certain it will work other than to create the labels

DYMO Connect on the App Store

Your best option would be to contact Dymo support and ask them about what there printer can do with an iPad

http://www.dymo.com/en-US/online-support

ways to print with ios devices such as ipads

1. the printer support apples generic airprint interface and is connected to the same wifi network About AirPrint - Apple Support

2. find a printing app in app store which support the model of printer (many manufactures have apps I use one from Samsung for my wifi Samsung printer)

3. not sure if it still the case but awhile back if one installed netgear genie on a computer it would make all printers it had drivers for work as airprint enabled printers for ios devices on the network

ways that will not work is usb connected or the likes directly to the ios device