Mac keyboard and mouse not working while other thing seems ok

Try running this program in your normal user account, then copy and paste the output in a reply. The program was created by etresoft, a frequent contributor. Please use copy and paste as screen shots can be hard to read. Click “Share Report” button in the toolbar, select “Copy Report” and then paste into a reply. This will show what is running on your computer. No personal information is shown. You can run the report for free at least once, but if you run it several times, at some point it will ask you to pay a license fee.

Etrecheck – System Information

A Safe Mode boot deletes system caches that might help.

To start up in safe mode:

1. Start or restart your Mac, then immediately press and hold the Shift key. The white Apple logo appears on your display. If you don't see the Apple logo, learn what to do.
2. Release the Shift key when you see the login window. If your startup disk is encrypted with FileVault, you might be asked to log in twice: once to unlock the startup disk, and again to log in to the Finder.

To leave safe mode, restart your Mac without pressing any keys during startup.

Then see if the problem persists.

Use safe mode to isolate issues with your Mac - Apple Support