I'm in the same position as you.
Here is my story:
The day after I've had my new Mac 2018, it started to crackle because I thought it was because of Ableton 10 since it was the only ''big'' software I've installed after getting my Mac.
And I was playing a song at the loudest level possible on my new Mac and eventually, the crackling problem with my speakers became even worse than the crackling itself to the point I thought I had broken down my speakers!
The sound coming out of them was ****: it started with some major crackles/distortion followed by delays/repeating sections of the song while it was playing to finally transform the nature of the sound coming out of my speakers!! And all of a sudden, I was left with no bass/mids in my speakers AT ALL. It was as if playing this song too loud destroyed some kind of internal twitter in the speakers... At that point, I was very scared that it was broken for ever and super disappointed that the Mac just couldn't handle the sound being played a little louder than usual...
So I started to make some research about my problem and see if I was the only one facing the same problem and that's how I found this forum.
So I decided to reset EVERYTHING and delete everything that I had transferred from my old Mac to this new one just to see if doing a major rebooting would solve my problem.
So after completely restarting my Mac 2018, like the first time opening it, resetting the whole thing like it's brand new again actually solved the crackles and the other big issue that happened before with the quality sound of my speakers!!
At that point, I was just super happy that my Mac 2018 was back to normal again!!!
But I thought I could just wait to see if all these problems were gonna start again, since it seemed to be an issue entitled to Mac 2018...
So I've waited a while before actually installing Ableton again or transfer anything else/files to see if the crackling had something to do with any imported softwares or files. So at that point, all I was doing was to watch plenty of videos on YouTube or just listening to some music on Spotify and wait for the crackles to show up again.
AND IT DID (after 2 or 3 days of using the speakers quite intensively).
Conclusion...:
IT HAS NOTHING TO DO WITH F*CKING TIME MACHINE GUYS!!!
2nd part of my story:
I decided not to get my new Mac 2018 replaced by another one because what's the point of getting a new one with which there's a very good chance I might be confronted with the exact same problem again?!...
So I tried to even the sample rates of the mic and the speakers (48 000 Hz) and that seems to work nicely for now. but if it doesn't I'll definitely share my experience here again...