Strange transparent box on screen; cannot move or delete it
I suddenly got a strange horizontal, transparent box in the middle of my screen on my iMac, and I can't move it, delete it, or anything. When I click on it, it is as if I clicked on what is under it, which I can see, but of course it is maddening. I have no idea what put it there. But I want to get rid of it!!!!!!!! I have restarted my computer, to no avail.
In searching for answers, I see references to System Preferences, Mouse or Accessibility, and they reference options that are not shown in my system (Sierra 10.12.??)
I would be so grateful for some help with this!
iMac, macOS Sierra (10.12.6)