i've recently run into this problem as well after installing 10.5 via DVD and then updating to 10.5.4 via software update. I'm a professional musician and a mute computer is a $2000 doorstop to me.
i recently installed skype v2.7, which seems to instantly change the sound preference pane to include Soundflower (2ch) and Soundflower (16ch) in the list of audio input and output devices. last week i tossed the com.apple.audio.DeviceSettings.plist, com.apple.SystemSettings.plist, and com.skype.skype.plist files, restarted, and it seemed to solve the problem. today, same drill and nothing.
here's the latest quotable quote from my log:
Aug 24 11:18:01 localhost kernel[0]: ^PSound assertion "0 == data" failed in "AppleOnboardAudio/AppleTopazAudio.cpp" at line 149 goto Exit
Aug 24 11:18:01 localhost kernel[0]: ^PSound assertion "0 == mCodecIOServiceArray[codecRef]" failed in "AppleOnboardAudio/PlatformInterfaceI2C_PlatformFunction.cpp" at line 380 goto Exit
Aug 24 11:18:01 localhost kernel[0]: ^PSound assertion "0 != result" failed in "AppleOnboardAudio/PlatformInterface.cpp" at line 1494 goto Exit
Aug 24 11:18:01 localhost kernel[0]: ^PSound assertion "0 != mPlatformInterface->readCodecRegister ( kCodec_CS8420, map
IDVERSION, &result, 1 )" failed in "AppleOnboardAudio/AppleTopazAudio.cpp" at line 867 goto Exit
Aug 24 11:18:01 localhost kernel[0]: ^PSound assertion "0 == data" failed in "AppleOnboardAudio/AppleTopazAudio.cpp" at line 149 goto Exit
Aug 24 11:18:01 localhost kernel[0]: ^PSound assertion "0 == thePluginObject" failed in "AppleOnboardAudio/AppleOnboardAudio.cpp" at line 4791 goto Exit
Aug 24 11:18:01 localhost kernel[0]: ^PSound assertion "0 == thePluginObject" failed in "AppleOnboardAudio/AppleOnboardAudio.cpp" at line 4350 goto Exit
Aug 24 11:18:01 localhost kernel[0]: ^P
Aug 24 11:18:06 localhost kernel[0]: Sound assertion "0 == thePluginObject" failed in "AppleOnboardAudio/AppleOnboardAudio.cpp" at line 5776 goto Exit
Aug 24 11:18:06 localhost kernel[0]: ^PSound assertion "0 == thePlugin" failed in "AppleOnboardAudio/AppleOnboardAudio.cpp" at line 2207 goto Exit
i wonder if apple should maybe open a new 'computers' division in addition to being a cellphone manufacturer.
we put these people where they are today.