iMac 24" 8,1 core duo 3.06 w/ Nvidia GeForce 8800 GS
Purchased mid 2008, so owned just barely over 2 year mark.
Wall-O-Text incoming...
I recently had similar issues (Nov 11th)... Just after the new osx update.
My screen began to artifact, pixels everywhere and audio would get caught in a loop, then finally the machine would just lock up. Sometimes this would happen with Photoshop open, sometimes, just copying or moving a file. The only resolve was to hold the power button.
Needless to say, it was dead. The screen artifacts and garbage were even present while running the Apple Hardware Test. The test showed nothing the first 3 times it ran. The fourth yielded a failing hdd. ( to be honest, I was experiencing issues near the end of October - pre 10.6.5 - but nothing this severe ).
I took it to the 3rd street Apple Store in Santa Monica, where they tried their best to help resolve everything quickly. It ended up being in their hands for a week, and the hdd and graphics card were replaced for roughly $640 (they dropped the price by $100) out of apple care (I never needed it over the past 13 years : live and learn).
I got the machine home on Nov 20th. All seemed well. It started up just like I purchased a new one (clean install) and lasted... a week.
On the Nov 27th(after applying the recent OSX updates again), something new happened. This time, the entire lower 50% of the screen started to flicker black over and over, until eventually, locking up. OpenGL log errors galore. I've seen some of the similar garbage on screen prior to the graphics card replacement, and am now about to drop kick this machine.
I'm almost resolved to the problem being with the logic board, but can't help but think that something in the latest update was the catalyst. Any updates tend to make the machine freak out again... I keep wiping and starting fresh. So far, 10.6.4, and 10.6.5 will eventually reproduce the issues. I don't understand at all.
I don't want to replace the logic board, as that will inevitably make me a sucker because I could have just bought a new 27"instead of lose nearly a month of work and play over this BS.
About to give up...