I'm having similar problems too. This weekend things took another strange turn though.
Config two monitors, 1 x BENQ (primary) connected via HDMI, 1 x LG connected via thunderbolt to DP.
Initially problem was second monitor, again LG connected via Thunderbolt to DP (Amazon cable), monitor would not wake and the only way to clear was to power off Mac mini and restart. This became annoying as it usually powered up in recovery mode which required a reboot to clear even if rebooting from the apple menu.
This seems to happen every two to three weeks of operation.
This weekend the BENQ monitor behaved a bit erratically and start showing what looked like static, after about 10 seconds it corrected itself and operated normally. I presumed this was a monitor problem.
This morning the same thing happened, the BENQ displayed static, for a few seconds, but instead of going back to normal it became green with a black mouse cursor which could be moved around.
Removing the HDMI cable moved the screen over to the LG, but re-inserting the HDMI to try to return to dual monitor caused the LG to stop showing any image.
I then tried disconnecting the LG and moving the HDMI from the BENQ and plugging into the LG, this showed the same green screen with black mouse I saw on the BENQ, which indicates the problem was generated from the Mac mini.
No matter what I tried nothing would get any of the screens working, eventually both would no longer show any image. I tried holding the power button down to turn off, waiting 30 seconds and powering back on, but still no image on either screen. Eventually I had to power off, unplug power cable, wait 30 seconds, re-insert power cable and power on to resolve.
Maybe I will try a different cable for the LG monitor, but the green screen issue I had was definitely the Mac mini as it followed whichever monitor was inserted into the HDMI port.
I hope the next release does resolve this as it makes my move to MacOS quite disappointing.
Anyway, posting this here in case someone else has seen the same issues, or it helps identify the cause.