How do I get "Mac Cleanup Pro" pop up off my system?

Fixes for Adware and Pop-ups

1. Malwarebytes
2. DetectX Swift
3. Remove adware that displays pop-up ads and graphics on your Mac
4. Stop pop-up ads and adware in Safari - Apple Support

Something else you can try.

Force quit Safari from the  menu and reopen with the shift key held down. If that doesn’t work, disconnect from the Internet, delete the web site from History, open Safari, and then reconnect to the Internet. See link for other suggestions.

Safari -Tech support scam pop-ups