Safari freezing, restarting Mac Pro 5,1 with Sapphire Pulse 580 GPU
I have a mid-2012 Mac Pro (yes, I know it's legacy but it's still a good machine) with the recommended Sapphire Pulse 580 8GB GPU and dual mini 6-pin to 8-pin power cable installed. (3.2 GHz Quad-Core Intel Xeon, 32 GB 1066 MHz DDR3 (2 x 16), Mojave 10.14.)
Everything is working well apart from Safari beachballing, freezing and restarting the Mac Pro. I can't identify the source of the issue but suspect it's something to do with some web graphics/media tech conflicting with the GPU. Twitter is one website that always causes a restart. I've tried other browsers (Firefox, Chrome) and haven't (yet) come across the issue with them.
Unfortunately, it's not possible to do a safe boot with this GPU but the same issue is happening in both my admin and day-to-day user accounts. I've tried disabling and uninstalling Safari extensions and system add-ons like Little Snitch, resetting PRAM and the SMC, Disk Utility repair, Onyx, EtraCheck (no major issues), TechTool Pro (no issues), reinstalling Mojave and, finally, a clean install on my Samsung SSD 860 EVO 500GB without migrating data.
Any ideas? Switching the default browser is an obvious workaround, yes, but this is clearly a bigger issue that I'd like to get to the bottom of before it causes any more problems.