if I set wrist detection off then the watch does not lock except when I put it on the charger, and I am running the same apps (Weather, Now Playing, Activity Monitor, Calendar).
Ah, good clarification. It's clear an interaction between the wrist detection setting and something going on with the apps.
I initially thought the problem was the wrist detection setting in general, so I tried tightening and loosening the strap, jumping up and down, etc. I could never get it to do anything.
Then I started launching apps, and I could get it to repeatedly crash in an app and immediately dump to the lock screen.
If you google the issue of "apple watch keeps locking" it's clear that in the past there have been problems with the sensors themselves. It seems to me that is NOT the problem here, but some sort of interaction between the wrist lock setting and something running on WatchOS 6.0.1.
Does your wife's watch have the wrist lock set to ON or OFF?
I guess this gives me the option of continuing to run 5.3, or upgrade to 6.0.1 and turn off wrist detection. I've owned an Apple Watch since the Series 0 and have always used wrist detection.