The iTunes WiFi sync settings doesn't appear along VPNs and profiles under General settings and disappears when unplugged from computer even though it's enabled in iTunes

Hello and welcome to Apple Support Communities, MusicalCoder.

If I understand your post correctly, you are trying to enable Wi-Fi sync with iTunes. I’d like to help.

Follow these steps:

Sync your content using Wi-Fi

After you set up syncing with iTunes using USB, you can set up iTunes to sync to your device with Wi-Fi instead of USB.

Connect your device to your computer with a USB cable, then open iTunes and select your device. 

Click Summary on the left side of the iTunes window. 

Select "Sync with this [device] over Wi-Fi." 

Click Apply.

When the computer and the device are on the same Wi-Fi network, the device appears in iTunes. The device syncs automatically whenever it's plugged in to power and iTunes is open on the computer.

See the full article here:

Use iTunes to sync your iPhone, iPad, or iPod with your computer

Let us know if that resolves this issue for you. 

Thanks for using the Apple Support Communities. Take care.