For the amount of RAM you have on the computer, you are running a lot of programs. It appears you are running a VPN, possibly 2. Try quitting them and see if it helps.
I would uninstall CleanMyMac 4 using the Developer's uninstall instructions. Most posters recommend not using cleaning programs. They can destroy normal computer operations.
I would uninstall Avast. It tends to interfere with the computer's operation while providing minimal to no benefit unless you work with Windows files. Most long time posters recommend not using antivirus software or cleaning software such as CleanMyMac.
Avast
Avast Un-install
Try going to System Preferences/Profiles and disabling/deleting all profiles found there.
Go to System Preferences/Users & Groups and remove all login items. Restart the computer and do not open any programs except Safari. Test.