Please follow this procedure to determine if the problem is isolated to your Mac, or lies elsewhere.
- Shut down your Mac.
- Load macOS Recovery by holding ⌘ and r (two fingers) while you start your Mac with a third finger.
- When the macOS Utilities screen appears, release those two fingers.
- Choose Get Help Online.
- Safari will launch, but it will lack your bookmarks, favorites, history and other preferences.
Peruse your usual websites and determine if the phony pop-ups appear while using Safari in that mode. It probably won't.
If the problem does not occur in Recovery mode, but returns after restarting your Mac normally, please read If Safari is slow, stops responding, quits unexpectedly, or has other issues - Apple Support. The applicable section is likely to be "Remove Internet plug-ins and other add-ons" and the Support documents that follow "Learn more".
None of the Internet Plug-ins that appear in the report you posted are required for normal operation, so I suggest you remove all of them. For example, the Internet Plug-Ins, Input Methods, InputManagers, and ScriptingAdditions folders it describes in that Support document are either completely empty or absent on the Macs I typically use.
If you remain unable to resolve the problem, please write back.
