If it's a third party app, it won't work in Big Sur. So, all of them.
Because kernel extensions tie directly to the OS at the kernel level, a poorly written extension can destabilize the entire OS. Malicious kernel extensions can do just about anything they want since the kernel is at the root of the OS. Kicking all .kext files out removes these problems.
All vendors must now use Apple's EndPoint Security layer for apps that need continual access. Mouse, tablet and keyboard drivers being the most common, but there are more. Works somewhat the same as a kernel extension, but does not have as deep of a connection to the OS as the older .kext method.