For those waiting for a Sophos fix to Big Sur, looks like it will be awhile...
Known issues between Sophos Home and macOS 11 Big Sur - Updated December 2nd, 2020
- Time Machine backups to NETWORK locations are currently failing when Sophos Home is installed on Big Sur macOS 11 - Users will see a message reading "Time Machine couldn't complete the backup - The disk is already in use" This issue is currently under investigation by our development team. As a workaround, run the backup in Safe mode. We expect this issue to be resolved by March of 2021.
Separately, re: the AFP & SMB protocols. A couple of times my Time Machine bundle got corrupted. I've found out the hard way that SMB is much more stable than AFP. While AFP may still work on earlier MAC OS, do yourself a favor and switch to SMB.