As the topic imply, I have issues with a setup of 2 external monitors running with Mac OS Big Sur 11.1. (Issues was already with 11.0)
I work in a mixed environment with Windows & Mac which some would argued is "Not supported", but it worked absolutely fine with MacOS Catalina.
Setup:
2 x HP Z27n G2 (2560x1440)
Daisy-chained via DisplayPort and connected to a HP USB-C Dock G5.
Dock via USB-C to MacBook Pro. Using 2 different models:
15-inch, 2018 (GPU: Radeon 555X)
13-inch, 2019 (GPU: Intel Iris Plus Graphics 655)
Due to the fact that MacOS does not support MST it will only see 1 Monitor connected to the Dock
(Windows see both on 1 cable)
I have therefor connected a separate USB-C cable from the MacBook to monitor 2.
Issues:
When connecting the MacBook to the docking station it is random if it finds 1 monitor connected to the dock.
When the docking station is connected the Mac is unresponsive for a few seconds. (Cursor cannot be moved)
Goes for the 15-inch with dual GPUs.
13-inch with just one GPU does not freeze up and monitor is found most of the time.
When the monitor 1 is identified from the Dock the image "twitches" randomly.
Twitching happens with both models, independent of GPU.
The Mac directly identify monitor 2 connected directly with USB-C (No lock-up)
Monitor 2 over USB-C works without issues, no twitching.
This all worked perfectly fine with Catalina, no issues.
I have seen many posts relating to monitor issues and this thread points to all issues I myself experience.
I have no remedy, unfortunately, I only add my own experiences / issues.
Personally I experience more issues in the dual GPU setup, but the general "twitching" glitch is constant.