Solved: Epson Perfection 2450 wouldn't scan after Big Sur - "failed to open a connection to the device (-21345)
When I upgraded to Big Sur, my Epson Perfection 2450 stopped working. Every time I opened Image Capture, it would find the scanner (showed up in the interface) and try to preview, but then throw an error: "failed to open a connection to the device (-21345)"
From other posters on this forum, I tried re-setting the PRAM, but that didn't work.
The solution was to go into settings>printers and scanners, click "+" and just add the scanner. I don't think I had to do that pre-Big Sur - the system seemed to just know that the scanner was there. After upgrading to Big Sur, it stopped working, but going to the settings panel and adding the scanner there fixed the problem.