iMac: some websites won't open in Safari after Big Sur 11.3 update
I started a similar thread already and marked it "solved" because I was having the same issue on both my MacBook Air and my iMac running Big Sur 11.3. In Safari certain websites weren't opening, most notably is Facebook. The suggestion was made to reboot in Safe Mode and try the websites, and if they worked in Safe Mode, reboot and they should then work. This method worked for my MacBook Air (so I marked the last thread "solved" as I assumed wrongly that this would work with my iMac also), but it did not work for my iMac.
So for the iMac I reinstalled the system (Big Sur 11.3), then, after realizing those websites still didn't work, I again rebooted in Safe Mode, and they still didn't open. Strange because they work fine in Opera. Any suggestions?