This is what worked for me. Wired ethernet 2018 Mac Mini previously on 10.14 Mojave with zero issues using Chrome. Upon upgrading to Monterey, Chrome and Chrome Canary was not working properly. I have a special launcher since my Chrome profiles are on an external disk to offload disk wear.
After the initial upgrade, everything was okay. However this next morning, Canary would not even see an internet connection on the custom profile location, and Chrome was lagging/buffering on YouTube with NEVER happens. I was afraid that Monterey screwed up this ability, as running Chrome with the default profile on the main disk didn't have the problem. That's when I came searching for network issues, because this definitely wasn't normal.
I created a new network location, and turned off Limit IP Address Tracking. That fixed Chrome Canary at least getting internet connectivity.
EDIT: While it technically worked, my connection speed is still much more poor and not what it should be. There's still something going on. This is incredibly frustrating.