Hi to all and thanks to all for your help comments,
After a lot of months and Monterey upgrades, the same problem here with MacBook Pro 16 (intel i9) and two displays plug in TB3 with DisplayPort in OWC device...
I think before read this post, that it's the problem, becouse I work on my MBP with the MBP closed.
I think that is a crossed problems about Mission Control, Dock and perhaps another actor: Keyboard (I work with the original Keyboard of my older Mac Pro, plugin in hub usb across OWC ThunderBolt 3 )
I solved my issue with this terminal commands, Kill Dock, and another that I don't read on this tread, Enable Mission Control
At the moment, after this Commands, I works fine without any issues. I put this here.
If killing the Dock doesn't work, you can add an extra command to enable Mission Control first. The command will activate Mission Control by modifying the preference file of Dock (com.apple.dock.plist) located in ~/Library/Preferences.
How to fix Mac Mission Control not working:
1 Open Terminal.
2 Input the command below and press Enter to enable Mission Control.
defaults write com.apple.dock mcx-expose-disabled -bool FALSE
3 Execute the following command to restart Dock.
killall Dock
Hopefully, you no longer face macOS Mission Control not working after applying this fix.
I solved my problems with this couple commands
Best wishes!
(I found this help commands in a web page, iBoysoft <<<Thanks!)