Hello hariwebdesigns,
Welcome to Apple Support Communities!
If we understand your post correctly, mouseover and scrolling have stopped functioning on your mouse and keyboard. We'd like to help!
Try the steps provided in the article below for help with connecting your Bluetooth accessory to your Mac.
Connect a Bluetooth device with your Mac
The article below could be beneficial to you as well. There could be some kind of interference that is preventing it from connecting.
Resolve Wi-Fi and Bluetooth issues caused by wireless interference
We also recommend starting in safe mode. Sometimes just starting in this mode and then restarting can resolve issues like this: How to use safe mode on your Mac
Do any other USB devices work in that port?
Does the mouse work with any other device/Mac?
Have you tried a different USB cable?
Keep us updated.