Wacom Desktop Center not responding / Wacom tablet recognised only in certain mac accounts

Hi m3_

If lllaass suggestion to Safe-Boot the Mac does not resolve the problem try these steps in order.

1. Disconnect the tablet if USB hard-wired linked, or switch off the tablet power if WiFi/Bluetooth linked until step10.
2. Leave the tablet disconnected/powered off and restart the Mac.
3. After the Mac restarts go to the Applications folder and drag the Wacom folder to the Bin then empty the bin.
4. Return to the Applications folder and go to Utilities > Activity Monitor, open "Activity Monitor".
5. In Activity Monitor click the "CPU" button in the window header, then click the column header "Process Name" twice.
6. Scroll down the list of running processes and look for the following entries, select each in turn and click the "X" in the Activity Monitor window header, then from the pop-up context menu click "Force Quit", com.wacom.DataStoreMgr, com.wacom.IOManger, com.wacom.UpdateHelper, these processes may take a while to stop, up to five minutes, please be patient. If the processes will not stop after five minutes try repeating again.
7. Once all three processes have been halted close Activity Monitor and on the desktop ribbon-menu click Go > Computer > Macintosh HD > Library > PrivilegedHelperTools. In the folder "PrivilegedHelperTools" delete the following files only: com.wacom.DataStoreMgr, com.wacom.IOManger & com.wacom.UpdateHelper. Note: You can only delete these files if the associated services were successfully stopped previously in Activity monitor. If you see the message "unable to delete the file x.x because the file is in use" this means its service is still running. If this should occur then restart the Mac in Safe-Mode and repeat from step 4 above, note that in Safe-Mode your mouse commands and keyboard entries will appear "laggy" this is normal for Safe-Mode working, please be patient while repeating steps 4 though 9 in Safe-Mode.
8. If your Wacom tablet has been installed for some time, over previous macOS builds, return to the library folder and scroll down the list looking for a folder called "Tablet". Open that folder, if it exists, and delete any Wacom files that are found there. This folder may not exist on more recent macOS builds, or with more recent installations of the Wacom software.
9. After the files com.wacom.DataStoreMgr, com.wacom.IOManger & com.wacom.UpdateHelper have been deleted from the folder "PrivilegedHelperTools" and any Wacom files found in the (possible) folder "Tablet" have been removed, empty the bin and restart the Mac.
10. After the Mac has rebooted plug-in or power-on the Wacom tablet.
11. Delete any previous versions of the Wacom installer package from your Downloads folder then visit the Wacom web site and re-download the latest official driver package for your model tablet and macOS version and run the installer.
12. During the installation process you will be asked to grant permission for the Wacom tablet to be able to control your computer, grant permission and then check this was accepted by opening System Preferences > Privacy and in the the left-pane scroll to "Accessibility" then click the "Padlock" symbol, bottom of the window, enter password, then right-pane "Allow the apps below to control your computer" if missing, place a check against the entry for com.wacom.IOManager. Next, in the left pane scroll to "Input Monitoring" and in the right pane under "Allow the apps below to monitor input from your Keyboard even while using other apps" place a check against WacomTabletDriver.
13. Click the "Padlock" symbol to re-lock the Privacy tab in Security and Privacy and restart the Mac for a final time.

Is the tablet now working in your prime user account?

If you are using a Bluetooth linked Wacom tablet and you have an Intel based Mac then update to Monterey platform, build 12.2.1, released yesterday, Thur 10th Feb 2022, as it has an important fix for the Bluetooth service.

The above steps are usually successful in restoring Wacom tablet support in macOS Catalina, Big-Sur and Monterey.

If the above steps are unsuccessful then I don't know of any other fixes and you should try contacting Apple tech support and/or Wacom tech support directly. You can contact Apple tech support by clicking the link at the top of this web page "Get Support".

HTH

Will.

Try booting to Safe Mode. That boot up takes minutes and clears caches and other things that may resolve your problem.

How to use safe mode on your Mac - Apple Support

A lot of times just boot to Safe Mode followed by normal boot resolves problems.

Have you tried reinstalling the latest drives when logged into the problem account(s)?

Hi m3_ & colinrm

You could try deleting the .plist files also, since these store the Wacom persistent settings per-user.

Follow my last guide (above, and reposted below) through to step 9, you have deleted the three Wacom files in the Macintosh HD > Library > PrivilegedHelperTools folder and checked for a possible Wacom file in the "Tablet" folder, if that folder exists, but before emptying the bin and restarting the Mac go to Macintosh HD > Library > Launch Agents and delete the files com.wacom.DatastoreMgr.plist, com.wacom.IOManger.plist and com.wacomtablet.plist, then empty the bin and restart the Mac, then continue on from step 10 in the guide, connecting the tablet and reinstalling the Wacom software.

For your convenience I have edited and added that step to my previous guide and reposted below, unfortunately I can't go back and edit the original post.

I searched the entire Mac for other Wacom files and could find none so maybe these .plist files are the ones that are preventing the Wacom Desktop Center from responding and finding your tablet.

(If you are using Bluetooth to connect the tablet to the Mac check in the Mac Bluetooth utility (System Preferences) that the tablet is detected and paired).

HTH

Will.

1. Disconnect the tablet if USB hard-wired linked, or switch off the tablet power if WiFi/Bluetooth linked until step10.
2. Leave the tablet disconnected/powered off and restart the Mac.
3. After the Mac restarts go to the Applications folder and drag the Wacom folder to the Bin then empty the bin.
4. Return to the Applications folder and go to Utilities > Activity Monitor, open "Activity Monitor".
5. In Activity Monitor click the "CPU" button in the window header, then click the column header "Process Name" twice.
6. Scroll down the list of running processes and look for the following entries, select each in turn and click the "X" in the Activity Monitor window header, then from the pop-up context menu click "Force Quit", com.wacom.DataStoreMgr, com.wacom.IOManger, com.wacom.UpdateHelper, these processes may take a while to stop, up to five minutes, please be patient. If the processes will not stop after five minutes try repeating again.
7. Once all three processes have been halted close Activity Monitor and on the desktop ribbon-menu click Go > Computer > Macintosh HD > Library > PrivilegedHelperTools. In the folder "PrivilegedHelperTools" delete the following files only: com.wacom.DataStoreMgr, com.wacom.IOManger & com.wacom.UpdateHelper. Note: You can only delete these files if the associated services were successfully stopped previously in Activity monitor. If you see the message "unable to delete the file x.x because the file is in use" this means its service is still running. If this should occur then restart the Mac in Safe-Mode and repeat from step 4 above, note that in Safe-Mode your mouse commands and keyboard entries will appear "laggy" this is normal for Safe-Mode working, please be patient while repeating steps 4 though 9 in Safe-Mode.
8. If your Wacom tablet has been installed for some time, over previous macOS builds, return to the library folder and scroll down the list looking for a folder called "Tablet". Open that folder, if it exists, and delete any Wacom files that are found there. This folder may not exist on more recent macOS builds, or with more recent installations of the Wacom software.
9. After the files com.wacom.DataStoreMgr, com.wacom.IOManger & com.wacom.UpdateHelper have been deleted from the folder "PrivilegedHelperTools" and any Wacom files found in the (possible) folder "Tablet" have been removed, go to Macintosh HD > Library > LaunchAgents and delete the files: com.wacom.DatastoreMgr.plist, com.wacom.IOManger.plist and com.wacomtablet.plist, exit the library, empty the bin and restart the Mac.
10. After the Mac has rebooted plug-in or power-on the Wacom tablet.
11. Delete any previous versions of the Wacom installer package from your Downloads folder then visit the Wacom web site and re-download the latest official driver package for your model tablet and macOS version and run the installer.
12. During the installation process you will be asked to grant permission for the Wacom tablet to be able to control your computer, grant permission and then check this was accepted by opening System Preferences > Security & Privacy, click the Privacy tab and in the the left-pane scroll to "Accessibility" then click the "Padlock" symbol, bottom of the window, enter password, then right-pane "Allow the apps below to control your computer" if missing, place a check against the entry for com.wacom.IOManager. Next, in the left pane scroll to "Input Monitoring" and in the right pane under "Allow the apps below to monitor input from your Keyboard even while using other apps" place a check against WacomTabletDriver.
13. Click the "Padlock" symbol to re-lock the Privacy tab in Security and Privacy and restart the Mac for a final time.

Does this fix the problem?

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All - your feedback above has been hugely useful as I also tried everything listed and still with the same result - desktop centre just does not respond. I then created another user profile - and it all works perfect without even re-installing. So it has to be related to a service / file that's within your profile. Will continue to try and isolate what service within my old profile has been conflicting with Wacom. At least now I have a last resort solution of migrating to a new profile.