Canon color profiles missing in Photoshop

Since it happens intermittently it could be a corrupt cache file. Give this a try: boot into Safe Mode according to How to use safe mode on your Mac and test to see if the problem persists. Reboot normally and test again.

NOTE: Safe Mode boot can take up to 3 - 5 minutes as it's doing the following; 

• Verifies your startup disk and attempts to repair directory issues, if needed

• Loads only required kernel extensions (prevents 3rd party kernel/extensions from loading)

• Prevents Startup Items and Login Items from opening automatically

• Disables user-installed fonts 

• Deletes font caches, kernel cache, and other system cache files

Hi yukon819,

If you're having issues with the Photoshop application, you can find Adobe's support site here: Adobe Help Center

It sounds like you're also unable to setup a printer on your computer. You can find the steps to setup different printer types here: Add a printer to your printer list so you can use it on Mac

If you have multiple printers set up on the computer already, you can use these steps to set a default one: Choose your default printer on Mac

Hope this helps. Cheers!