Scroll Wheel Stopped working....

I've not used a scroll wheel mouse for years but when I did I occasionally had problems which were mechanical caused by a buildup of skin grease. My solution was to use a lightly moistened Q-tip and to rotate the wheel against the tip.

I found this article which comes up with other suggestions.

https://big-photography.com/guides/do-logitech-mice-work-with-mac-2/

With regards to it being a Mac software issue is not accurate, it is the responsibility of the third party hardware manufacturer to ensure compatibility with the latest version of MacOS.

I am not a mind reader and you did not make any mention of contacting Logitech so my answer was spot on and to the point. If you were offended it was likely because you did not write with much context, please read Writing an effective Apple Support Communities Question so you can get an idea of what is needed.

It will help us get a good idea of what is causing your problem if you provide a report of your system, that way we do not have to play 20 questions with you. The report we are requesting does NOT provide any personal information and is extremely safe to use. Please navigate to www.Etrecheck.com and download the free version of EtreCheck. Once you have you downloaded the app and installed it, please run the report and save it. This report will help us get a good idea what has been installed on your system and help us be able to diagnose what may be wrong.

When you have your report, you can attach it when you reply to this message and we can then review it and help you determine what is needed to get your system running well again. 

For instructions on how to download your EtreCheck report and attach it to your reply to this message please click https://discussions.apple.com/docs/DOC-250000211

Please contact Logitech for support on their product.

Please don't tell them you tried "most everything", that tells them nothing. Be specific about what you have attempted as a fix.