NTFS external drives won't mount after security update 2021-003 (com.apple.DiskManagement.disenter error 49221.)

sizza64 wrote:

will wait until apple give us a new patch for this bug! thanks again!

I would not expect a fix from Apple since it is the third party vendor & developer who are responsible for making sure their third party app works with macOS. @PachisCruz's post later in this thread even proves that the problem is with the manufacturer's third party driver since after uninstalling the manufacturer's driver and rebooting, @PachisCruz was able to read the NTFS drive which shows that macOS is functioning fine and it is just the manufacturer's driver that has the problem. Of course macOS does not have native built-in write support for NTFS volumes, but at least the NTFS volumes can be read after uninstalling the drive manufacturer's software. See @PachisCruz's specific post I referenced here:

NTFS external drives won't mount after se… - Apple Community

This is why most contributors on these forums recommend against using the manufacturer's proprietary software for managing drives because the proprietary third party drivers may break after a macOS update and users will need to wait until the third party developer fixes the problem (if they even do so). Using a native built-in file system included by default with macOS is always the safest and most reliable option.