Installed Monterey, unable to use Wacom tablet

Wacom and I finally figured out what the problem was last night. (The tech emailing me was still on the wrong path, but after I got Laura on Chat we got it figured out.) Turns out the problem was the latest Wacom driver update. Updating to 6.3.46-1 caused all the problems. A total uninstall of all Wacom software and a reinstall of version 6.3.44-2 fixed everything.

FYI: https://cdn.wacom.com/u/productsupport/drivers/mac/professional/WacomTablet_6.3.44-2.dmg

[This is a Direct Download Link]

I have the exact same issue, I have done everything they suggest, allow thru privacy, uninstalled and reinstalled, it seems like its a permissions issue from privacy in Mac and even after you add the drivers in it apple does not allow control. I have had this issue since Catalina. I made it work until now that Monterey is out and no luck at all.... Wacom has videos and tech support spend hours trying with no luck. very disappointing

I'm having the same problem, with both an Intuos and a BT tablet from Wacom. The strange thing is, I can eventually get it to work (after iterations of reinstalling drivers, manually copying a Touch driver over, etc.), but it seems that it dies immediately after I use the space bar to move around a zoomed in image (with the pen) in Photoshop. I think I may have done something similar in Capture One and killed it once. Not sure if this is an Apple problem or a Wacom problem.

Please ensure the software for your Wacom is up-to-date and is designed to work with Monterey. You may need to reach out to Wacom for support on their product.

"Up-to-date" Wacom driver was the problem. Rolling back to the prior 6.3.44-2 was the solution. The new version broke something.