Music app keeps opening automatically. It's frustratingly ideopathetic. What gives?

CleanMyMac is considered junk-ware by many long time users here and needs to go as per the developers instructions.

CleanerOne is another App that I would recommend ditching.

Plus you have numerous system modifications and plugins like AmazonMP3, Silverlight and others that I’ve never even seen before. At this point I can only suggest removing them one at a time to see if the issue stops.

Also if and when you started up in Safe Mode as suggested earlier, did that stop the Music issue or not. If it stopped, then that would definitely point to one of those third party App, Modification or Plug-in that is causing the problem.

That is strange?

Do you have an iPhone, iPod or MP3 player connected to the Mac Mini?

Do you have any third party music or music streaming app’s installed on the Mac Mini?

I would check to see if it happens in Safe Mode.

see > Start up your Mac in safe mode - Apple Support

Then check again after a normal restart.

It might also help us see the issue, if you run EtreCheck Pro on the Mac Mini.

https://etrecheck.com/

Then post back here with your EtreCheck Pro report.

https://discussions.apple.com/docs/DOC-250000211

You’re welcome. EtreCheck Pro was developed by a long time helper here in the forum. It dose not show any personal information and has helped countless thousands of users solve issues with their Mac’s.