Next time click on the Additional Text button and then paste the report in the window that opens up.
First, there is no reason to ever install or run any 3rd party "cleaning", "optimizing", "speed-up", anti-virus, VPN or security apps on your Mac. This user tip describes what you need to know and do in order to protect your Mac: Effective defenses against malware and other threats - Apple Community.
There are no known viruses, i.e. self propagating, for Macs. There are, however, adware and malware which require the user to install although unwittingly most of the time thru sneaky links, etc.
Anti Virus developers try to group all types as viruses into their ad campaigns of fear. They do a poor job of the detecting and isolating the adware and malware. Since there are no viruses these apps use up a lot of system resources searching for what is non-existent and adversely affect system and app performance.
There is one app, Malwarebytes, which was developed by a long time contributor to these forums and a highly respected member of the computer security community, that is designed solely to seek out adware and known malware and remove it. The free version is more than adequate for most users.
That being said you've installed what most of the users here consider akin to malware, CleanMyMac. uninstall CleanMyMac according to the developer's instructions. Run for a while and then rerun Etrecheck to verify that there are no files remaining with either CleanMyMac or MacPaw in the file name.
In the second report check to see if it still reports a failing hard drive under Major Issues.
Major Issues:
Anything that appears on this list needs immediate attention.
Failing hard drive - This computer has a hard drive that appears to be failing.
If it still reports a failing hard drive make sure you have a full and complete backup. You might want to consider getting an external SSD, clone your boot drive to it with Carbon Copy Cloner and boot and run from the external SSD.
NOTE: be aware that at the time of purchase you bought the slowest Mac that Apple offered: 8 GB RAM and a 5400 rpm hard drive.
It would be much more expensive to try to replace the hard drive in the Mini than to get an external SSD to use. And you can take the SSD with you when you upgrade your Mac.