How to edit extensions shortcuts on Safari for Mac

Thanks for the explanation. If the particular Safari Extension offers a key combination to activate / deactivate it (and assuming that key combination is editable), that would be found in the settings for that particular Extension. Open the Safari menu > Preferences... > Extensions to determine if either one of those Extensions offers such a setting.

If the Extension installs an icon in the Safari Toolbar, try clicking that icon.

I suppose you could ask their developers to consider implementing editable key combinations. Tell them they conflict with each other.

It's not something you could fix with Safari.

Change Extensions preferences in Safari on Mac - Apple Support

I'm not quite sure what you mean by "extensions shortcuts" though.