Hello mrhooks,
Is the issue only happening with Safari, or are you experiencing issue with other apps as well? That will help us plan how to proceed.
If apps aren't opening or working as expected, please be sure to check out the suggestions outlined in this link, which may help with that issue: If an app on your Mac stops responding, closes unexpectedly, or won’t open
"1. Quit and reopen the app
Quit the app, then open it again. If the app won't quit, force the app to quit. Then check to see if the problem with the app is fixed.
2. Restart your Mac
Restart your Mac. Then check to see if the problem with the app is fixed.
3. Check for updates
To see if updates are available for the app, open the App Store, then click Updates. If updates aren't available for the app, update the software on your Mac. Or if you didn't get the app from the App Store, look for updates to the app on the app developer's website. Then check to see if the problem with the app is fixed.
4. Reinstall the app
Delete the app. When you do this, you might lose data that was stored in the app. Then redownload the app. If you didn't get the app from the App Store, redownload the app on the app developer's website. Then check to see if the problem with the app is fixed.
Get more help
If Safari isn't opening webpages as expected, please check out this link as well, which has some additional information that may be helpful: If Safari on Mac doesn't open a webpage or isn’t working as expected
Thanks!