This MacBook Pro may have configuration profiles installed.

You are using a VPN. <ProtonVPN OpenVPN>

>System Settings>Privacy & Security

A true VPN tunnel, for example between you and your job, or a Bank server would be of value, otherwise might be time to re-think the usage.

see: Public VPN's are anything but private

https://gist.github.com/joepie91/5a9909939e6ce7d09e29

It is often recommended—Uninstall all third party apps that are Cleaners/Optimizers/Anti-Virus/VPN

all known to cause issues on the macOS

Not sure what etrecheck is querying for here " Configuration profiles "

this seems benign:

Some network printers may require you to install a configuration profile so that the printer can be discovered on your network using AirPrint.

If you are provided a profile to install, download or copy the printer profile to your Mac and then install it. On your Mac, double-click the profile to open it.

Unsigned Files:

Running app: ~/Library/Printers/Brother HL-L2370DW series-1.app/Contents/MacOS/PrinterProxy

Running app: ~/Library/Printers/Printer ThermalPrinter.app/Contents/MacOS/PrinterProxy

Running app: ~/Library/Printers/HP ENVY Inspire 7200 series.app/Contents/MacOS/PrinterProxy

Running app: ~/Library/Printers/Brother HL-L2370DW series.app/Contents/MacOS/PrinterProxy

Add a printer to your printer list so you can use it on Mac

Im not using a VPN though.

According to the EtreCheck report, you are. There are multiple listings of Proton VPN and OpenVPN.

There is nothing malicious in your EtreCheck report and no indication of any hacking activity.