Computer does not recognize keyboard or mouse since last update.

The following will require any USB keyboard and mouse. If you don’t have them, borrow or buy them, they are inexpensive!

1.     Connect the USB keyboard and mouse to the computer.

2.     Open System Preferences – Bluetooth

3.     Un-pair the wireless keyboard and mouse.

4.     Turn off Bluetooth

5.     Restart the computer in Safe Mode per the directions in How to use safe mode on your Mac - Apple Support

6.     Restart the computer normally.

7.     Open System Preferences – Bluetooth

8.     Turn on Bluetooth

9.     Re-Pair the wireless keyboard and mouse.

10.  Unplug the USB keyboard and mouse and begin testing the wireless devices again. 

Hi,

Following article could help your issue.

If you can't connect your Magic Keyboard, Magic Mouse, or Magic Trackpad to your Mac - Apple Support

Please restart the computer in Safe Mode and then retest.

By the way, is there any third party antivirus, cleaning, VPN, security or any other third party "maintenance" apps installed on the computer?

Your welcome.