Left click on my mouse stopped working after macOS Ventura update

I have the same issue after the update to 13.4.1 on my 16inch M1 MacBook Pro 2021. The primary click stopped working and restart didn't help. I restarted in recovery mode where everything was normal and proceed to reboot again when it momentarily fixed the problem until it came back again after a few minutes.

I called the apple support and they suggested to reinstall Mac OS from recovery mode. I did and it started working again however, it is intermittent. Read below behaviour post reinstall:

I have noticed that I can reproduce the problem by letting the MacBook sleep on its own due to inactivity. As soon as the display goes off, I press the click to wake it up again and the problem comes back. Note that you have to wake it up quickly otherwise if you leave it for more than a few seconds before waking it up again, it goes to the password prompt and not sure if it is reproducible that way.

Once it gets into this state, I have noticed that it fixes itself after leaving it for a while or restarting in recovery and then full restart. This is really disruptive and I have read some reddit posts where I am sure I am not the only one with this issue. Please fix or escalate.

[Personal Information Edited by Moderator]

Have you restarted? If not, do so and retest.

This is likely not helpful but I had the same issue and turned out to be a blue tooth mouse in my bag that was interfering.