Solebrotha, if you know how to use Terminal, I would say to use the commands below to clean up your mac. If not App Cleaner & Uninstaller from Nektony is the best choice!
After that we check the way external disks work.
But if you used the same disk for Time Machine and files for long time, you should see if it's full or not!
To start with I would say unload agents and then delete them from your system! If you are not feeling ok with Terminal use only AppCleaner to clean!
sudo launchctl unload /Library/LaunchDaemons/com.microsoft.EdgeUpdater.update.system.plist
sudo rm /Library/LaunchDaemons/com.microsoft.EdgeUpdater.update.system.plist
sudo launchctl unload /Library/LaunchAgents/com.epson.pma.launcher.plist
sudo rm /Library/LaunchAgents/com.epson.pma.launcher.plist
sudo launchctl unload /Library/LaunchAgents/com.epson.esua.launcher.plist
sudo rm /Library/LaunchAgents/com.epson.esua.launcher.plist
sudo launchctl unload /Library/LaunchAgents/com.epson.Epson_Low_Ink_Reminder.launcher.plist
sudo rm /Library/LaunchAgents/com.epson.Epson_Low_Ink_Reminder.launcher.plist
sudo launchctl unload /Library/LaunchAgents/com.epson.eventmanager.agent.plist
sudo rm /Library/LaunchAgents/com.epson.eventmanager.agent.plist
You can completely uninstall old apps using Nektony's App Cleaner. I can see many in your EtreCheck report.
Shuffit Expander, Backup and Sync (old Google Drive), Epson apps, WD Discovery or other apps from WD, WinZip etc etc.
-- To replace WinZip you can use: Keka, The Unarchiver
Also there are some paths you need to clean to completely remove something like a Microsoft app. For Edge those are the ones:
use sudo rm in front of each path, like so:
sudo rm "~/Library/Application Scripts/com.microsoft.edgemac.wdgExtension"
"~/Library/Application Scripts/com.microsoft.edgemac.wdgExtension"
"~/Library/Application Support/Microsoft Edge"
"~/Library/Application Support/Microsoft/EdgeUpdater"
"~/Library/Caches/com.microsoft.edgemac"
"~/Library/Caches/com.microsoft.EdgeUpdater"
"~/Library/Caches/Microsoft Edge"
"~/Library/Containers/com.microsoft.edgemac.wdgExtension"
"~/Library/HTTPStorages/com.microsoft.edgemac"
"~/Library/HTTPStorages/com.microsoft.edgemac.binarycookies"
"~/Library/HTTPStorages/com.microsoft.EdgeUpdater"
"~/Library/LaunchAgents/com.microsoft.EdgeUpdater.update.plist"
"~/Library/LaunchAgents/com.microsoft.EdgeUpdater.update-internal.*.plist"
"~/Library/LaunchAgents/com.microsoft.EdgeUpdater.wake.*.plist"
"~/Library/Microsoft/EdgeUpdater"
"~/Library/Preferences/com.microsoft.edgemac.plist"
"~/Library/Saved Application State/com.microsoft.edgemac.app.*.savedState/"
"~/Library/Saved Application State/com.microsoft.edgemac.savedState"
"~/Library/WebKit/com.microsoft.edgemac"
Hope those help and restart after cleanup.. and post a new EtreCheck :)
