Unsupported hard drive configuration in PhotoLab on iMac

DXO – Help Center – Error "we have detected that some of your hard drives are configured in a way that is not supported by DxO PhotoLab." (macOS only)

There's an article by the people who make Carbon Copy Cloner on the same issue.

Bombich – Carbon Copy Cloner – "CCC found multiple volumes with the same Universally Unique Identifier"

The current version of CCC contains a "non-destructive" tool that can reset a drive's UUID. How safe it would be to run that tool on your external drive, is something I don't know. (I suppose you could ask DXO what they think about the CCC "Reset UUID" menu item.)

If DXO PhotoLab keeps a database of any sort – and you migrated data from an old Mac that had its own "Backup Drive 3", perhaps it is referring to a conflict between the UUIDs of

• The "Backup Drive 3" for the old Mac
• The "Backup Drive 3" for the new Mac

Just a thought …

I think you will have to reach out to the PhotoLab folks to see what is triggering this. To my mind, it should not care about any drives it does not use.